IFNL4 polymorphisms predict sustained response and HBsAg clearance in interferon treated HBeAg negative chronic hepatitis B patients

s / Digestive and Liver Disease 47S (2015) e43–e66 e49 those without, F2-F4 fibrosis compared to those without(72% vs 44%, respectively; p =0.04). After correction for confounders, significant fibrosis was associated with S02 mean levels≤95% mean oxyhemoglobin saturation(SaO2) levels 1% was maintained(OR 6.30,95%C.I.1.0212.3;p =0.01). Conclusions: In NAFLD patients without morbid obesity OSAS was highly prevalent and indexes of oxygen saturation were independent indicators of the severity of liver fibrosis and of carotid atherosclerosis risk. These data, if further validated, could suggest to look at for OSAS in all NAFLD patients, considering OSAS as a potential additional therapeutic target for NAFLD. http://dx.doi.org/10.1016/j.dld.2015.01.106