Mean platelet volume/platelet count ratio and mortality in patients on peritoneal dialysis

OBJECTIVES: The association between mean platelet volume/platelet count ratio (MPV/PC) and mortality has been demonstrated in various populations but not in peritoneal dialysis (PD) patients. This study investigated the association between MPV/PC and all-cause and cardiovascular mortality in PD patients. MATERIALS AND METHODS: In this single-center retrospective cohort study, 338 patients who underwent incident PD from January 2006 to June 2014 and had baseline MPV/PC were enrolled and followed until June 30, 2015. RESULTS: The mean patient age was 50.5 ± 14.9 years (58.2% men, 22.8% diabetic). During a median follow-up of 25 (IQR 17 - 39) months, 58 patients died; 30 deaths were due to cardiovascular disease. The patients were stratified into two groups according to the PC, MPV, and MPV/PC quartiles. The all-cause and cardiovascular mortality were compared between both groups. MPV and MPV/PC and all-cause and cardiovascular mortality were significantly associated, even after adjusting for age, gender, Davies score, hemoglobin, albumin, and usage of platelet inhibitors. Only the association between baseline MPV/PC and all-cause and cardiovascular mortality was similar when we examined PC, MPV, and MPV/PC without stratification. In the multivariable adjusted model, each 0.01 increase in MPV/PC was associated with an adjusted hazard ratio (AHR) of 0.67 (95% CI, 0.51 - 0.89) for all-cause mortality and an AHR of 0.63 (95% CI, 0.42 - 0.96) for cardiovascular mortality. CONCLUSION: MPV/PC may be a more reliable and accurate risk factor compared to MPV or PC alone.
.