Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial

Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial By:Asemi, Z (Asemi, Zatollah)[ 1 ] ; Karamali, M (Karamali, Maryam)[ 2 ] ; Jamilian, M (Jamilian, Mehri)[ 2 ] ; Foroozanfard, F (Foroozanfard, Fatemeh)[ 3 ] ; Bahmani, F (Bahmani, Fereshteh)[ 1 ] ; Heidarzadeh, Z (Heidarzadeh, Zahra)[ 1 ] ; Benisi-Kohansal, S (Benisi-Kohansal, Sanaz)[ 5,6 ] ; Surkan, PJ (Surkan, Pamela J.)[ 4 ] ; Esmaillzadeh, A (Esmaillzadeh, Ahmad)[ 5,6 ] • 1Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran; • 2Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran; • 3Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran; • 4Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. • 5Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; and. • 6Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran esmaillzadeh@hlth.mui.ac.ir. Abstract Background: To our knowledge, prior research has not examined the effects of magnesium supplementation on metabolic status and pregnancy outcomes in maternal-child dyads affected by gestational diabetes (GDM). Objective: This study was designed to assess the effects of magnesium supplementation on metabolic status and pregnancy outcomes in magnesium-deficient pregnant women with GDM. Design: A randomized, double-blind, placebo-controlled clinical trial was performed in 70 women with GDM. Patients were randomly assigned to receive either 250 mg magnesium oxide (n = 35) or a placebo (n = 35) for 6 wk. Fasting blood samples were taken at baseline and after a 6-wk intervention. Results: The change in serum magnesium concentration was greater in women consuming magnesium than in the placebo group (+0.06 +/- 0.3 vs. -0.1 +/- 0.3 mg/dL, P = 0.02). However, after controlling for baseline magnesium concentrations, the changes in serum magnesium concentrations were not significantly different between the groups. Changes in fasting plasma glucose (-9.7 +/- 10.1 vs. +1.8 +/- 8.1 mg/dL, P < 0.001), serum insulin concentration (-2.1 +/- 6.5 vs. +5.7 +/- 10.7 mu IU/mL, P = 0.001), homeostasis model of assessment-estimated insulin resistance (-0.5 +/- 1.3 vs. +1.4 +/- 2.3, P < 0.001), homeostasis model of assessment-estimated beta-cell function (-4.0 28.7 vs. +22.0 43.8, P = 0.006), and the quantitative insulin sensitivity check index (+0.004 +/- 0.021 vs. -0.012 +/- 0.015, P = 0.005) in supplemented women were significantly different from those in women in the placebo group. Changes in serum triglycerides (+2.1 +/- 63.0 vs. +38.9 +/- 37.5 mg/dL, P = 0.005), high sensitivity C-reactive protein (-432.8 +/- 2521.0 vs. +783.2 +/- 2470.1 ng/mL, P = 0.03), and plasma malondialdehyde concentrations (-0.5 +/- 1.6 vs. +0.3 +/- 1.2 mu mol/L, P = 0.01) were significantly different between the supplemented women and placebo group. Magnesium supplementation resulted in a lower incidence of newborn hyperbilirubinemia (8.8% vs. 29.4%, P = 0.03) and newborn hospitalization (5.9% vs. 26.5%, P = 0.02). Conclusion: Magnesium supplementation among women with GDM had beneficial effects on metabolic status and pregnancy outcomes. Keywords:magnesium; supplementation; gestational diabetes; pregnant women; pregnancy