Phenotypically-Silent Bone Morphogenetic Protein Receptor 2 (Bmpr2) Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing The Risk for Neointimal Transformation

Wen Tian,Xinguo Jiang,Yon K. Sung,Eric M. Shuffle,Ting-Hsuan Wu,Peter N. Kao,Allen B. Tu,Peter Dorfmüller,Aiqin Cao,Lingli Wang,Gongyong Peng,Yesl Kim,Patrick Zhang,James Chappell,Shravani Pasupneti,Petra Dahms,Peter Maguire,Hassan Chaib,Roham T. Zamanian,Marc Peters-Golden,Michael Snyder,Norbert F. Voelkel,Marc Humbert,Marlene Rabinovitch,Mark R. Nicolls

Phenotypically-Silent Bone Morphogenetic Protein Receptor 2 (Bmpr2) Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing The Risk for Neointimal Transformation

2019

Background: Bmpr2 mutations are critical risk factors for hereditary pulmonary arterial hypertension (hPAH) with approximately 20% of carriers developing disease. There is an unmet medical need to ...

Keywords:

Disease
Internal medicine
Inflammation
Bone morphogenetic protein receptor
Diabetes mellitus
Cardiology
BMPR2
Medicine
Immunology
Endocrinology
Lung

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