Vesicular drug targeting in combating cerebral oxidative injury

Brain stroke is the main reasonforhealth disability and mortalityamong aged pupils worldwide. Mitochondrial dysfunction, due to oxidative stress during cerebral ischemia-reperfusion, exerts inflammations and damages to the neurones of the brain. Free form of antioxidant is basically inefficient for the treatment of cerebral ischemia as blood brain barrierremains in between systemic blood and brain interstitial fluid. Furthermore, the affectivity of antioxidant compounds may be hindered by their poor permeability, low solubility and enhanced rate of efflux from the effected cells. Therefore, different active compounds encapsulated in various vesicles have been investigated in vivo to prevent brain ischemia. Our review, on the methods applied for the preparation, characterization, and efficacy of vesicular active drug compounds -delivery, has demonstrated a promising aspect, especially for nanoencapsulation in the treatment of cerebral ischemia against oxidative cell death with higher biological effectiveness and least side effects.