Early Combination Therapy with Linagliptin and Metformin in People with Type 2 Diabetes Improves Glycemic Control to HbA1c </= 6.5% without Increasing Hypoglycemia: Pooled Analysis of Two Randomized Clinical Trials.
2020
INTRODUCTION: Clinical guidelines suggest a glycated hemoglobin A1c (HbA1c) target of 70%) of the 1160 patients analyzed were treatment naive, and more than half had had diabetes for = 1 year; mean baseline HbA1c was approximately 8.7%. Combination therapy with linagliptin and metformin resulted in more patients achieving HbA1c = 6.5% than metformin alone, both for a metformin dose of 500 mg (40.1 vs. 22.9%, respectively, odds ratio [OR] 2.84, 95% confidence interval [CI] 1.87-4.32) and 1000 mg (49.5 vs. 35.4%, respectively, OR 2.28, 95% CI 1.54-3.40). Hypoglycemia occurred in < 3% of patients, with a comparable incidence between treatment groups. Other adverse events were also balanced between groups. CONCLUSION: Early combination treatment with linagliptin and metformin can improve the chances of achieving tight glycemic control (HbA1c = 6.5%) without increasing the risk of hypoglycemia or other adverse events. TRIAL REGISTRATION: ClinicalTrials.gov, NCT00798161 and NCT01708902.
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