Neonatal tuberous sclerosis complex

Tuberous sclerosis complex is an autosomal dominant genetic disease, which has an incidence of 1/6 000 to 1/10 000.Clinical manifestations in TSC present age-dependency and the features of newborn are often untypical, which easily cause missed diagnosis and misdiagnosis.The magnetic resonance appearances of neurological lesions in neonates differ from those in older children and adults, and the imaging feature is very important for TSC diagnosis in neonatal period.This article reviews the clinical and imaging features and the progress of diagnosis and treatment of neonatal TSC. Key words: Newborn; Tuberous sclerosis complex