The difference of omentin mRNA expression in adipose tissues and its correlation with glucose metabolism in the patients with gestational diabetes mellitus

Objective:To explore the difference of omentin mRNA expression in subcutaneous and omental adipose tissues and its correlation with glucose metabolism in the patients with gestational diabetes mellitus(GDM). Methods:43 pregnant women with GDM and 43 normal pregnant women were paired according to age,parity,BMI before delivery and gestational weeks,the levels of fasting blood lipid before delivery in the two groups were measured,the subcutaneous and omental adipose tissues were obtained during cesarean section,RT-PCR was used to detect the expression levels of omentin mRNA in adipose tissues of different parts,the correlation between the expression level of omentin mRNA and OGTT result,prenatal lipid metabolism was analyzed. Results:The expression levels of omentin mRNA in subcutaneous and omental adipose tissues in GDM group were significantly lower than those in control group.Single factor analysis showed that there was a significant correlation between the expression level of omentin mRNA in omental adipose tissues and fasting blood glucose and 2-hour postprandial blood glucose of OGTT;while there was a significant correlation between the expression level of omentin mRNA in subcutaneous adipose tissues and 2-hour postprandial blood glucose of OGTT and prenatal HDL-C level.Multiple stepwise regression analysis showed the expression levels of omentin mRNA in subcutaneous and omental adipose tissues were independent predictors of 2-hour postprandial blood glucose of OGTT,the effect of omentin mRNA expression level in omental adipose tissues on 2-hour postprandial blood glucose of OGTT was larger. Conclusion:The relationship of glucose metabolism with omentin mRNA expression in omental adipose tissues is closer than its relationship with omentin mRNA expression in subcutaneous adipose tissues.