Abstract P034: Circulating Omega-3 Fatty Acids and Risk of Acute Myocardial Infarction in Singapore Chinese

Introduction: Omega-3 fatty acids have been associated with reduced risk of coronary heart disease, but it remains unclear whether plant-based alpha-linolenic acid (ALA) provide similar benefits as marine-originated eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and evidence from Asian populations is limited. Objective: We aimed to examine the association between plasma omega-3 fatty acid biomarkers, including ALA, EPA and DHA, and risk of acute myocardial infarction (AMI) in a Chinese population in Singapore, and to explore the potential biological mediators of their effects. Methods: We conducted a nested case control study with 759 incident fatal and non-fatal AMI cases and 796 matched controls selected from the Singapore Chinese Health Study, who were of ages 45-74 at the time of recruitment and free of cardiovascular disease at the time of blood collection. Plasma fatty acid biomarkers were measured using gas chromatography tandem mass spectrometry. Conditional logistic regression was us...