Evaluation of monocyte to high-density lipoprotein ratio, lymphocytes, monocytes, and platelets in psoriasis

Abstract Background Psoriasis is a chronic immune-mediated inflammatory skin disease that is associated with cardiovascular comorbidities. Objectives The objective of this retrospective study is to assess the C-reactive protein (CRP), monocyte-to-high-density-lipoprotein ratio (MHR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) as inflammatory markers in patients with psoriasis, and to search for a relationship between these parameters and psoriasis severity, as defined by the Psoriasis Area and Severity Index (PASI). Methods There were 94 patients with psoriasis and 118 healthy controls enrolled in the study. The CRP, MHR, NLR, PLR, and MLR values of two groups were retrospectively evaluated. Results Statistically significant differences were observed in terms of CRP, MHR, NLR, and MLR between the patient and control groups (p = 0.001, p = 0.003, p = 0.038, and p = 0.007, respectively). Positive correlations were found between the PASI score and the values of CRP, MHR, NLR, PLR, and MLR (r = 0.381, p = 0.001; r = 0.203, p = 0.045; r = 0.268, p = 0.009; r = 0.374, p = 0.001; r = 0.294, p = 0.004; respectively). Study limitations The small sample size and the retrospective design of the study are limitations. Conclusion Elevated CRP, MHR, NLR, and MLR were significantly associated with psoriasis. A positive correlation between CRP and MHR leads to the suggestion that MHR might be a reliable parameter in psoriasis during the follow-up. The relationship between the disease and inflammatory parameters might provide early detection of cardiovascular morbidities in psoriasis patients.