Mitochondria injury by amyloid-β peptide and it's function in Alzheimer's disease

Alzheimer's disease(AD) is a progressive neurodegenerative disease,which characterized by extracellular amyloid-β peptide(Aβ) plaques and intracellular neurofibrillary tangles(NFTs).The etiological factors and pathogenesis are still unclear.Amyloid-β peptide locates in mitochondria and it can induce a series of disorders in mitochondrial function,such as decreasing in ATP production,promoting oxidative stress,brokening the balance of mitochondrial fission/fusion and enhancing cellular apoptosis,and so on.