The Biogenesis, Transmission, Structural and Therapeutics on SARS-CoV-2 (COVID-19) Pandemic: Challenges and Global Perspective

The present pandemic situation due to the appearance of COVID-19 has put the world in a miserable condition. About 2.5 million people have been infected with the strain of coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) globally. The foremost patient of COVID-19 infection was identified in China in the month of December 2019. Researchers are searching for an effective method to combat this pandemic virus. The investigations have been regulated by the scientists towards finding effective medicine, vaccine as well as robust techniques to detect and combat this virus. Furthermore, the evolution of new treatments, the application of clinical data analytics has also been observed for the off-label use of the already available approved medications. As a real-time application of science and technology, numerous clinical trials have been under process to find out the best medicine against the COVID-19 pandemic. The present study summarizes in the form of a comprehensive review conscripting the available knowledge about identification, genomic structure, and mode of infection, and clinical importance of SARS-CoV-2. Currently, available approaches for the detection of COVID-19 have been highlighted along with available treatments which have been explored by researchers worldwide includes precisely convalescent plasma therapy, monoclonal antibody therapy as well as antiviral agents from natural and synthetic sources, and regulatory status have been discussed elaborately which will enrich the global understanding as well as proficient ability to combat this pandemic pathogen