Sa1855 Group II Metabotropic Glutamate Receptors in the Dorsal Motor Nucleus of the Vagus (DMV) Mediate Changes in Pancreatic Exocrine Secretion in Acute Pancreatitis

flux. Conclusions: Ethanol alone does not stimulate autophagosome formation due to excessive LC3-II delipidation by Atg4. In contrast, ethanol+ low-dose CR pancreatitis decreases Atg4 and stimulates autophagy. Both ethanol and alcoholic pancreatitis cause lysosomal dysfunction resulting in impaired autophagic flux. The results support our "2-hit" hypothesis that a combination of 1) autophagy induction, and 2) lysosomal dysfunction causing impaired autophagic flux, are both critical in the mechanism of alcoholic pancreatitis.