The role of extracellular matrix in allergic contact dermatitis pathogenesis

Abstract Allergic contact dermatitis (ACD) is the most common dermatopathy, caused by topical exposure to chemical allergens and resulting in “sterile inflammation.” Significantly, almost 20% of the general population presents ACD to at least one or more contact allergens. It is indicated that that ACD could be accountable for as much as 50%–60% of occupational contact dermatitis with a significant economic impact. Robust risk assessment and efficient therapy for ACD are still unmet health needs. The extracellular matrix (ECM) provides tissue structure, specificity, and organization and regulates cellular functions and responses in homeostasis and disease by triggering specific signaling pathways. The ECM is extensively remodeled during the progression of ACD, and the released/altered ECM mediators contribute significantly to various aspects of ACD pathogenesis. ECM-originating effectors are promising therapeutic targets and could be employed for the development of novel risk assessment methodologies for ACD.