DECREASED FERRITIN AND INCREASED HEPCIDIN SERUM LEVELS IN PERIODONTITIS PATIENTS WITH DIABETES MELLITUS TYPE 2: A CONTROLLED BEFORE-AND-AFTER STUDY

Objectives: The aim of the present work is to estimate the level of ferritin & hepcidin in serum of patients suffering from periodontitis and diabetes mellitus type 2 T2DM before and after non-surgical periodontal treatment.Subjects and methods: Our study included 60 patients, categorized into 3 groups. 20 individuals with stage II grade B generalized periodontitis with T2DM (Group I), 20 others with stage II grade A generalized periodontitis (Group II) and 20 healthy volunteers (Group III). We obtained two serum samples from periodontitis patients before and after treatment in addition to one sample from each control subject. Serum ferritin & hepcidin levels were determined by using Enzyme linked immunosorbent assay technique (ELISA). Results: The ferritin level was significantly higher in periodontitis groups than control in contrast to hepcidin that was eleveted in control group. A significant decrease in ferritin concentration but increase in hepcidin was noticed after 3 months. Receiver Operating Characteristic (ROC) curve analysis demonstrated more significant accuracy for ferritin than hepcidin on comparing both periodontitis groups with control.Conclusions: As a prognostic marker for periodontitis, we could use ferritin but not hepcidin.