Evaluation of risk of stroke and effect of intervention in patients after transient ischemic attack

Objective To evaluate the risk of stxoke in patients after transient ischemic attack(TIA),and study the effect of intervention with antiplatelet drug.Methods 256 patients with TIA were randomly divided into intervention group and control group(128 in each group).All patients were treated with routine treatment,and in addition the antiplatelet dnlg(clopidogrel,75 mg/d)was added to the intervention group,placebo was added to the control group.After 7 days,1 month,3 months and 6 months,comparative analysis were made between two groups in incidence,clinical symptom,sign and neurological function defects scofe(with EdinburghScandina stroke scale.MESSS)of stroke patients.And the hemorheology indexeswere observed.Results After7 days.1 month.3 months and 6 months,the stroke incidences of control group were 8.59%,14.06%,21.09%and 28.13%.In intervention group.the incidences were 0.00%,4.69%,8.59%and 11.72%.The difference was,ignificant(P＜0.05).In pathological reflex,brain infarct area and MESSS of stroke patients,the differences were significant(P＜0.05)betweeen two groups.After treatment,there were also significant difference(P＜0.05)in hemorheology indexes of patients.Conclusion The stroke incidence of patients after TIA was significantly highter than general population,and Secondary Prevention of Stroke must be performed early.Antiplatelet drug is safe and effective for stroke prevention. Key words: Transient Isehemic Attack(TIA); Stroke; Secondary Prevention of Stroke