237: Phosphatidylcholine distribution between lipoprotein fractions in patients with CAD

Background and objectives Recent data have shown that phospholipids (mainly phosphatidylcholine) transfer activity is associated to metabolic syndrom and coronary artery disease (CAD). This transfer activity could modulate the phosphatidylcholine (PC) distribution between lipoprotein subclasses. In this study we separated lipoprotein fractions and we analyzed PC distribution. Methods Ninety two subjects were recruited (47 CAD patients and 45 age- and sex-matched controls). Antropometric measurements, lipid profile and PC analysis were performed. Results Despite from an abnormal lipid profile: elevated serum triglycerides and LDL-C, and low HDL-C (but total cholesterol level was not significantly different between controls and CAD patients), serum PC centrations were slightly higher in CAD patients than in controls (respectively 2.53±0.84 and 2.36±0.43 mmol/L, ns). The level of PC was significanly higher in patients, compared to controls, concerning the (VLDL+LDL) fraction ( p p p =0.0013). However, PC concentrations were less closely associated to BMI in the same group (p Conclusion Serum phospholipid status is modulated in patients with CAD. This involves a significant modulation of the PC distribution between lipoprotein subclasses and probably reflects an abnormality in the phospholipid transfer activity (PLTP activity) representing a useful marker of cardiovascular risk.