ASSA13-11-7 Distributional Characteristics of Genetic Polymorphisms of Serum Amyloid Protein A1 in Healthy Chinese Han and Uighur Population in Xinjiang

Objective To explore the distributional characteristics of genetic polymorphisms (rs2229338 and rs12218) of serum amyloid protein A1 (SAA1) in healthy Chinese Han and Uighur population of Xinjiang. Methods 316 Uighur and 362 Han healthy persons were detected the genotypes of the SAA1 by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results The genotype distributions of the Uighur group and the Han group were in the Hardy-Weinberg equilibrium (both P > 0.05). The frequencies of AA, AG and GG of rs2229338 were 76.6%, 23.4%, and 0 in Uighur group while ones were 91.7%, 7.7% and 0.6% in Han group. There was significant difference in distribution of genotypes between these two groups (P Conclusions The mutational frequencies of the tagging SNP (rs2229338 and rs12218) in the SAA1 gene of Uighur population were higher than those of Han.