Non Alcoholic Fatty Liver Disease and Degree of Steatosis in Diabetic and Non- Diabetic Patients

Abstract Background Non-Alcoholic Fatty Liver Disease (NAFLD) and diabetes mellitus (DM) frequently coexist. Intrahepatic fat accumulation, insulin resistance, and the released inflammatory signals may have a role in both. Aim:To assess NAFLD and degree of steatosis in diabetic patients compared to non-diabetic controls. Also, to determine NAFLD relation to the clinical and the biochemical data of the diabetic patients. Methods A case-control study was conducted in the Family Medicine Clinics and Fibroscan Unit, Cairo University Hospital recruiting 76 type2 diabetic patients and 80 non-diabetic subjects. A full history was taken then clinical examination; investigations and controlled attenuation parameter (CAP) were done. The data were analyzed by SPSS version 20. Results The diabetic patients had a higher prevalence of NAFLD than the non-diabetic participants (92.1%) vs (72.5%) respectively. Mild, moderate and severe degrees of steatosis were (2.6%), (40.8%) and (48.6%) vs (5%), (46.2%) and (21.3%) in diabetic and non-diabetic participants respectively. Among diabetic patients, female gender, smoking, increased BMI, insulin therapy and increased proteins level were associated significantly with NAFLD. Conclusion Type 2 DM is strongly associated with NAFLD. Alongside this, DM is significantly associated with advanced degrees of steatosis.