Aldehyde content of collagen from liver of rats with collagen-like syndrome
1983
Summary Collagen was obtained from liver tissue of rats with hydralazine-induced collagen-like syndrome. Bacterial collagenase was used to solubilize the collagen, and the aldehyde content of this material was measured using N-methyl benzothiazolone hydrazone. The aldehyde content was decreased in the collagen from livers of rats with collagen-like syndrome. The changes in hepatic collagen may be analogous to the effect of aging on collagen, wherein collagen cross-linking is strengthened although qualitative changes in cross-linking may lower the measurable aldehydes.
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