Some aspects of antioxidant protection in patients with tuberculosis after lung parenchyma sparing resection

Lung Parenchyma Sparing Resection (LPSR) is the most common type of surgical treatment for pulmonary tuberculomas in Russian Federation. The goal of our study was to estimate some aspects of operational stress in patients with lung tuberculomas who undergone LPSR. Material and Methods: Blood levels of neoptrerin, cortisol, superoxide dismutase, and total antioxidant activity of blood plasma (AAP), the total number of amino acids (AA) and their percentage were examined in all patients (n=42) before and 3 weeks after LPSR. Results: In all patients, the postoperative period was uneventful. The concentration in blood of neopterin, oxystat, cortisol, superoxide dismutase after surgery has not changed. There was a significant decrease in AAP and the total number of AA after LPSR. There was a significant increase of concentration of aspartic acid (from 0,9 ± 0,01 to 1,3 ± 0,01), proline (from 2,7 ± 0,1 to 4,3 ± 0,3), and AA, involved in the synthesis of glutathione-taurin (from 1,3 ± 0,01 to 3,3 ± 0,02), cysteine (from 1,7 ± 0,01 to 2,3 ± 0,1) detected after surgery. Conclusion: In patients operated for for pumonary tuberculoma with a favorable postoperative period there were some homeostasis changes, characterized by a marked shortage of antioxidant system, and increase of concentration of AA involved in the synthesis of glutathione and asparagine those we count as typical compensatory reaction for surgical intervention. These data suggest that there was a need for correction of antioxidant resources by use of amino acids involved in the synthesis of glutathione in patients undergone LPSR.