Insulin Deficiency Impairs Thyroid Peroxidase Activity: A Study in Experimental Diabetes Mellitus

Various abnormalities of thyroid function have been described in diabetes mellitus. Clinical, as well as subclinical, hypothyroidism have been shown to occur with increased frequency in insulin-dependent diabetes (1). Alloxan or streptozotocin (STZ)-induced diabetes is associated with a decrease in basal and TSH-stimulated thyroid function in animals (2,3).