Study on efficacy and safety of adding insulin detemir in poorly controlled type 2 diabetes patients

Objective To study the efficacy and safety of adding once-daily insulin detemir in the patients with poorly controlled type 2 diabetes.Methods 30 cases of type 2 diabetes with poor glycemic control by oral antidiabetic drugs were treated with once-daily insulin detemir added to previous drugs for 12 weeks.Fasting plasma glucose(FPG),HbA1c and weight were measured before and after treatment,and hypoglycemia was also noted.Results After 12-week treatment,FPG and HbA1c were both significantly decreased than before(the decreased value of FPG and HbA1c 4.4-6.1 mmol/L and 2.6%,P0.01).Weight was increased by 0.6 kg,but no statistical difference existed compared to before(P0.05).During treatment,only 1 hypoglycemia event was observed,and no severe adverse events were noted.Conclusion The treatment of once-daily insulin detemir added to oral antidiabetic drugs in the patients with poorly controlled type 2 diabetes is not only effective in the glycemic control,but also is low in the risk of hypoglycemia and little in the weight gain.