Effect of short-term acumagnetotherapy on diabetic kidney disease in patients with type II diabetes and study on the molecular mechanism

Abstract Objective To explore whether magnetotherapy is preventive in retarding diabetic kidney disease (DKD) progression and investigate underling molecular mechanisms related to its therapeutic efficacy. Methods Twenty-eight patients with type II diabetes (T2D) were undergone pulsed electromagnetic fields (PEMF) stimulation at the acupoints of Pishū ( BL 20), Zusānl ( ST 36), Shenshū ( BL 23) and Yishū ( , EX-B3) for a period of 4 weeks. Urinary micro-albumin (U-mAlb) excretion, plasma methane dicarboxylic aldehyde (MDA and lipopolysaccharide (LPS) of the patients were used for evaluating therapeutic efficacies. Results After the acumagnetotherapy, U-mAlb excretion in the participated patients was markedly reduced (27.21±3.51 vs 8.51±0.95, P P P P P P P Conclusion Short-term intervention of acumagnetotherapy in patients with T2D mitigates DKD progress potentially by its anti-oxidative and anti-inflammatory effects.