No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C.
2011
Background. Heme oxygenase-1 (HMOX1) and bilirubin
UDP-glucuronosyltransferase (UGT1A1), both enzymes involved in
bilirubin homeostasis, play an important role inoxidative
stress defense. Objective. To assess the effect of
promotervariations of HMOX1 and UGT1A1 genes on the progression
of fibrosis in patients chronically infected with the hepatitis
C virus (HCV). Material and methods. The study was performed
on146 chronic HCV infection patients, plus 146 age- and
sex-matched healthy subjects. The (GT)n and (TA)n dinucleotide
variations in HMOX1 and UGT1A1 gene promoters, respectively,
were determined by fragment analysis in all subjects. Results.
No differences were found in the frequencies of each particular
allele of both genes, between HCV patients and a control group
(p > 0.05). Furthermore, no association was detected (p > 0.05)
between either the HMOX1 or the UGT1A1 promoter variants and
the individual histological stages of liver disease in the HCV
positive patients. Finally, no differences in the HMOX1 and
UGT1A1 genotype prevalence rates were found between
pre-cirrhotic and cirrhotic patients (p > 0.05). Conclusion.
Based on our data, microsatellite variations in the HMOX1 and
UGT1A1 genes are not likely to protect from progression of
liver disease in patients with chronic hepatitis C.
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