Resumption of Ovarian Function and Pregnancies in 358 Patients with Premature Ovarian Failure

Context: Resumption of ovarian activity and spontaneous pregnancies are described in patients with premature ovarian failure (POF), but there is a lack of data concerning the prevalence of and predictive factors for these phenomena. Objective: The aim of the study was to determine both the prevalence of and predictive factors for spontaneous resumption of ovarian function in POF patients. Design and Setting: A mixed retrospective and prospective study was performed at a referral center for reproductive endocrinology. Patients: A total of 358 consecutive POF patients were followed from 1997 to 2010 in our center. Main Outcomes Measures: The cumulative incidence of resumption of ovarian function was determined, and predictive factors were identified by univariate and multivariate analysis. Results: Of 358 patients with idiopathic POF, 86 (24%) patients presented features indicating resumption of ovarian function, and in 77 cases (88%) within 1 yr of diagnosis. Twenty-one spontaneous pregnancies (16 births, ...