AB0592 A Study of Short Term Progression of Takayasu Arteritis

Background Takayasu arteritis (TA) is a rare large vessel vasculitis predominantly affecting young females in Indian subcontinent. Objectives To know predictive factors for progression of Takayasy arteritis. Methods Retrospective proforma based analysis of all patients diagnosed with TA with minimum two year followup and followup imagining at two centersfrom 2007-2012 was performed. Results Data of 42 patients was available [31 (73.81%) females and 11 (26.19%) males] with mean age of 32.7±12.6 (16-54) years. Mean delay in diagnosis 2.9±2.2 (0.25-10) years.Absent peripheral pulse and arterial bruits were present in 24 (57.14%) and 33 (78.57%) patients respectively. 5 (11.90%) patients diagnosed in prepulseless stage with pyrexia of unknown origin (PUO) with high ESR. Mean ESR 63±29 mm/hr (8-135) and mean CRP 28±22 mg/dl (4-90). All treated with steroidsand immunosuppressants by treating physician. New onset arterial bruit or loss of pulse was found in 16 (38%) and 7 (16.66%)patients respectively. (Table-1)Of the 5 patients who presented in prepulseless stage, 2 had no further progression.At 2 year follow up mean ESR (p=0.03) and mean CRP (p=0.01) were associated with new onset pulse loss. Conclusions Patients with persistently high ESR and CRP were more prone for new onset arterial bruit or loss of palpable pulse. References Misra R, Danda D, Rajappa SM, Ghosh A, Gupta R, Mahendranath KM, Jeyaseelan L, Lawrence A, Bacon PA; Indian Rheumatology Vasculitis (IRAVAS) group. Devlopment and initial validation of the Indian Takayasu Clinical Activity Score (ITAS 2010).Rheumatology (Oxford). 2013 Oct;52(10):1795-801 Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.6087