Rapid nutritional promotion causes abnormal glucose metabolism

According to the survey conducted by the Chinese Center for Disease Control and Prevention, the prevalence of type 2 diabetes in China reached 10.9% in 2013, 20-fold increase over the early 1980s. In the recent two decades, the incidence of diabetes in our country has risen up significantly, which is related to catch up growth caused by the rapid promotion of nutrition. It has been revealed that catch up growth can result in thermogenesis suppression, dysfunction of adipose tissue, lipid ectopic deposition in skeletal muscle, liver inflammation, impaired function of intestinal-pancreatic axis and islet β cell injury, leading to visceral fat accumulation and insulin resistance, thus increasing the risk of type 2 diabetes. Therefore, it is of great significance to deeply explore the mechanism of catch up growth and to find effective intervention strategies for the prevention and treatment of type 2 diabetes in China.