Fully Automated Production of 11C-Doxepin for PET Imaging Histamine H1 Receptor
2012
Objectives
11C-Doxepin is an established positron emission tomography (PET) probe for imaging the histamine H1 receptor, which is associated with various neurological disorders and allergic diseases. A fully automated current Good Manufacturing Practices (cGMP)-compliant radiosynthesis is therefore desirable in order to facilitate clinical PET studies. We report here a fully automated production method for 11C-doxepin using a multipurpose PET module for clinical use.
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