Response to Letter Regarding Article, “Early Treatment With Lisinopril and Spironolactone Preserves Cardiac and Skeletal Muscle in Duchenne Muscular Dystrophy Mice”

Thank you for the insightful comments regarding our work.1 We have not yet explored the level of renin-angiotensin-aldosterone system activation in this model, which might help shed light on underlying mechanisms by which the drugs studied produce their benefits. However, one study of muscle biopsies from patients with Duchenne muscular dystrophy shows upregulation of angiotensin-converting enzyme in dystrophic in comparison with normal muscle.2 Because …