Wpływ insulinooporności na stężenie wybranych parametrów biochemicznych w grupie kobiet z zespołem policystycznych jajników

Introduction: Polycystic Ovary Syndrome is the most common recognized endocrinopathy in women. Early detection of carbohydrate and fat metabolism disorders in women with the syndrome allows the early prevention of cardiovascular diseases and type II diabetes. The purpose of this study was to assess the differences between the biochemical parameters in a group of women with insulin resistance (IR(+) PCOS) and without insulin resistance (IR[–] PCOS). Material and methods: The study was conducted in a group of 45 women hospitalized in the endocrinology department who met the Rotterdam criteria of PCOS syndrome. Insulin resistance was assess with HOMA-IR index. In accordance with the guidelines of the European Group for the Study of Insulin Resistance, we adopted HOMA-IR Results: The group of women aged 18-38 years (26.4 ± 5.6) entered the study. Significant differences were found between the group of women IR(+) PCOS and the group IR(–) PCOS in terms of mean values of: HDL cholesterol (mg/dl) (54.96 ± 13.35 vs. 66.72 ± 17.56; p = 0.0193), SHGB (nmol/l) (36.64 ± 21.09 vs. 71.28 ± 33.48; p = 0.0008), insulin (uU/ml) (14.78 ± 6.06 vs. 6.70 ± 2,68; p Conclusion: Insulin resistance was associated with differences in the studied biochemical parameters. Index HOMA-IR may be easy and effective tool to assess insulin resistance, thereby risk of cardiovascular diseases, type II diabetes and hyperandrogenaemia among polycystic ovary syndrome women.