NF-KB INHIBITION PROTECTS AGAINST MYOCARDIAL ISCHEMIA/REPERFUSION INJURY VIA ACTIVATION OF ANTIAPOPTOTIC SIGNALING

The molecular details of nuclear factor-kappaB (NF-kB) signaling during myocardial ischemia/reperfusion (I/R) injury remain poorly understood. We hypothesized that inhibition of NF-kB would prevent cell death. We used transgenic mice overexpressing a mutant IkBα with consequent cardiac-specific