Common NOD2/CARD15 and TLR4 Polymorphisms Are Associated with Crohn’s Disease Phenotypes in Southeastern Brazilians

Yolanda Faia Manhães Tolentino,Paula Peruzzi Elia,Homero Soares Fogaça,Antonio José V. Carneiro,Cyrla Zaltman,Rodrigo S. Moura-Neto,Ronir Raggio Luiz,Maria da Gloria da Costa Carvalho,Heitor S. de Souza

Common NOD2/CARD15 and TLR4 Polymorphisms Are Associated with Crohn’s Disease Phenotypes in Southeastern Brazilians

2016

Yolanda Faia Manhães Tolentino
Paula Peruzzi Elia
Homero Soares Fogaça
Antonio José V. Carneiro
Cyrla Zaltman
Rodrigo S. Moura-Neto
Ronir Raggio Luiz
Maria da Gloria da Costa Carvalho
Heitor S. de Souza

Aim To investigate whether variants in NOD2/CARD15 and TLR4 are associated with CD and ulcerative colitis (UC) in a genetically admixed population of Rio de Janeiro, where IBD has continued to rise.

Keywords:

Diabetes mellitus
Medicine
Phenotype
NOD2
Ulcerative colitis
Single-nucleotide polymorphism
Inflammatory bowel disease
Immunology
Population
Crohn's disease
Genotype
Case-control study
Genetics

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