The Relationship Between Motor Symptom Lateralization And Non-Motor Symptoms (NMS) In Parkinson’s Disease Patients (P4.058)

OBJECTIVE: The study aims to compare the non motor symptoms in Parkinson’s disease patients with respect to their side of dominant motor symptoms BACKGROUND: Parkinson’s disease (PD) the second most common Neurodegenerative diseases affecting between the age group of 50 and 70 years old. The Parkinson’s disease patients present with a wide range of motor and non-motor symptoms. There has not been much reporting on the motor symptom lateralization and its relationship with the non motor symptoms in patients with PD. DESIGN/METHODS: We collected data regarding the non motor symptoms in patients diagnosed with Parkinson’s disease, who attended the Movement Disorder Clinic in Cleveland Clinic at Weston, over the last 12 months. The dominant side affected with motor symptoms were documented for these patients. The standard self administered Non-Motor symptom questionnaire was filled out for each patient RESULTS: There were 100 patients in the study group with 59 males, 41 females, mean ± Standard Deviation (SD) of age was 68.05 ± 9.75. There were 38 patients (38%) with left dominant motor symptoms and 39 patients (39%) with right side dominant motor symptoms. The mean ± SD of Non-Motor (NMS) in the study population with Parkinson’s disease was 9.71 ± 5.41. The mean ± SD of Non-Motor symptoms in the left and right dominant Parkinson’s disease is 8.71±5.14 and 9.79±4.86 respectively. A median NMS of 8 and 8.5 is observed in left and right dominant Parkinson’s disease respectively. CONCLUSIONS: Neither the left or right dominant motor symptoms in Parkinson’s disease patients have any significant difference in their NMS score. Disclosure: Dr. Khan has nothing to disclose. Dr. Boddepalli has nothing to disclose. Dr. Reyes has nothing to disclose.