Survey of thrombophilia causes in patient with deep vein thrombosis admitted in Sari's Imam Khomini Hospital during 2009

Introduction: Thrombophilia is a condition in which there is a tendency for clot formation and has an incidence of 1 per 1000 annually. About 2/3 of attacks occurs as DVT and the remainder as PE or associated with DVT. Knowing these hereditary factors can be helpful in designating a proper diagnostic template when after it will be possible for each thrombophilic patient to be diagnosed in its proper way. Materials and methods: This is a descriptive study. Our patients were 70 DVT patients whom were bedridden at Imam hospital, Sari, Mazandran, Iran. After admission, they underwent heparin therapy followed by warfarin therapy for 6 months. In the next stage warfarin was stopped and after 2 weeks of heparin therapy, required lab tests were requested. Needed data were collected by a questionnaire and data were processed by SPSS18 statistical software. Findings: 22 people (31.4%) were males and 48 people (68.6%) were females. Mean age was 42.06±14.6 y. 12 of patients (17.1%) had diminished levels of factor V Leiden while 58 people (82.9%) had normal levels. In 84% of patients there were normal levels of fibrinogen and other 14% had increased levels of fibrinogen. Result: View this table: Table 1. Results Conclusion: Our study shows that DVT is most common in females. In through of non lab factors, OCP, history of no activity and trauma is more companionship with incidence of DVT. In through of genetic factors, FVL and high level of fibrinogen and low level of S protein are common.