Correlation Analysis of Concentration of Plasma Soluble CD28 and Graves Disease

th , 2014; revised: Apr. 7 th , 2014; accepted: Apr. 14 th , 2014 Abstract Objective: We did this research to discuss the clinical importance of measuring plasma soluble CD28 in Graves' disease, and explore correlation of soluble CD28 and FT3, FT4, sTSH, TRAb of plasma from Graves disease, and analyze diagnostic value of soluble CD28 in Graves' disease. Me- thods: Using the sandwich ELISA for detecting soluble CD28 and TRAb levels in plasma from healthy donors and patients with Graves' disease, we analyze the concentrations of FT3, FT4, sTSH through chemiluminescence immunoassay, simultaneously. Results: Our results have suggested that mean concentrations of soluble CD28 detected in patients with Graves' disease (3.34 ± 0.62 ng/ml) were significantly higher than those in healthy subjects (0.76 ± 0.21 ng/ml) (p 5 ng/ml) in plasma of peripheral blood of some Graves patients had significant positive correlation with goiter (p < 0.05) and exophthalmos (p < 0.01). Conclusion: The soluble CD28 had higher levels in patients with Graves' disease than those in healthy donors, and revealed positive correlation with FT3, FT4, TRAb. Therefore, soluble CD28 can be considered as an important biological parameter to support the diagnosis of Graves' disease.