The roles of serum free light chain ratio in the diagnosis and prognosis of newly diagnosed multiple myeloma

Objective The roles of serum free light chain ratio (sFLCR) in the diagnosis and prognosis of newly diagnosed multiple myeloma (NDMM) patients were analyzed. Methods The clinical data was retrospectively analyzed for 82 newly diagnosed multiple myeloma (NDMM) patients in the first affiliated hospital of Soochow University from September 28, 2012 to July 18, 2105. The serum free light chain levels were measured and κ/λ ratios were calculated, so we could analyze the roles of sFLCR in the diagnosis and prognosis of newly diagnosed multiple myeloma (NDMM) patients. Results It was 85.5% (70/82) positive of M protein by serum protein electrophoresis (SFE) and 93.9%(77/82) by serum immunofixation electrophoresis (IFE). Both sFLC and sFLCR abnormalities were 96.3% (79/82). The estimated 40-months overall survival was 87% for the high free light chain ratio group (sFLCR ≥100 or≤0.01) and 61% for the low free light chain ratio group (0.01

Keywords:

• Oncology
• Free Light Chain
• Multiple myeloma
• Diabetes mellitus
• Internal medicine
• Medicine
• Hemodialysis
• Creatinine
• Statistical significance
• Myeloma protein
• Gastroenterology
• Induction chemotherapy
• Serum protein electrophoresis
• Immunoglobulin light chain

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