Effects of curcumin on levels of nitric oxide synthase and AQP-4 in a rat model of hypoxia-ischemic brain damage.

Abstract This study examines the preventive and therapeutic effects of curcumin on brain edema after hypoxic–ischemic brain damage (HIBD) in a rat model. Male Sprague-Dawley rats were divided into four groups: a sham group (SH), a hypoxic–ischemic group (HI) without drug treatment, a hypoxic–ischemic group (CU) with curcumin injection, and a hypoxic–ischemic group with DMSO injection (solvent control, SC). HIBD treatment led to edema and ultrastructural changes in the hippocampus, increased the activity levels of nitric oxide synthase (NOS) in the brain ( P P P