Abstract 10883: C-GRApH: A Validated Scoring System for the Early Risk Stratification of Neurologic Outcomes After Out-of-hospital Cardiac Arrest Treated With Therapeutic Hypothermia

Background: Out of hospital cardiac arrest (OHCA) has 90% mortality, primarily from neurologic injury. Due to a lack of accurate early risk stratification models, guidelines advocate delayed prognostication of neurologic outcomes (NO) ≥72 hours post OHCA in patients treated with therapeutic hypothermia (TH). Here, we derive and validate a scoring system that uses objective data available at hospital presentation to risk stratify NO early post OHCA in the TH era. Methods: Demographics, pre OHCA diagnoses, arrest characteristics, and initial lab studies were compared between favorable and poor NO at hospital discharge, defined as cerebral performance category (CPC) 1-2 and 3-5 respectively, in a derivation cohort of 122 consecutive adult patients treated with TH (32-34 oC) post OHCA at a tertiary care US hospital from 2008-12. Inputs meeting a priori cutoffs ρ<0.1 in univariate and ρ<0.05 in subsequent stepwise multivariable analyses were dichotomized to create a scoring system (C-GRApH) with equal weightin...