Radiologic progression during intramuscular methotrexate treatment of rheumatoid arthritis.

The radiographic evolution of joint lesions in 41 patients with severe and longstanding rheumatoid arthritis (RA) treated with methotrexate (MTX) was studied in a double blind manner by 2 rheumatologists using Larsen's score. MTX does not appear to be able to slow down the radiographic evolution of RA