LACK OF ASSOCIATION BETWEEN TC786 POLYMORPHISM AND ALZHEIMER'S DISEASE IN IRAN

Alzheimer's disease (AD) is a advanced neurodegenerative disorder with complex and Multi-factorial pathogenesis. There are many common risk factors such as NOS3 gene TC786 polymorphism that play key roles in the development of Alzheimer's disease (AD). Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated to late onset Alzheimer's disease in a some populations. However, other groups failed to replicate this finding in other populations such as Asiatic and Caucasian. Evidence suggests that NOS3 might play a role in Alzheimer's disease (AD), as a result we Studied eNOS common polymorphisms (TC786 polymorphism) in Iranian patient affected by Alzheimer's disease (AD). Materials and methods: We conducted study including a clinically well- defined group of 52 Alzheimer's disease (AD) patients to test the association between NOS3 TC786 polymorphism and AD in Iranian population. In the present case control study, the eNOS polymorphisms (TC786 polymorphism) has been investigated in 52 Alzheimer's disease (AD) patients and 100 healthy subjects by using ARMS-PCR methods. Then, the data were analyzed by Pasw statistics 18 (SPSS) software. Results and Conclusion: The results of this study did not show significant association between Alzheimer's disease (AD) and NOS3 gene TC786 polymorphism in Iranian population.