HIGHLY ABSORPTIVE CURCUMIN IMPROVES LEFT VENTRICULAR DIASTOLIC FUNCTION REGARDLESS OF BLOOD PRESSURE IN HYPERTENSIVE PATIENTS

Asrac Caegor: 13. Hear ailure: Therapreseaio Numer: 1215-164Auhors: Tatsuya Morimoto, Hiromichi Wada, Yoichi Sunagawa, Masatoshi Fujita, Hideaki Kakeya, Atsushi Imaizumi, Tadashi Hashimoto, Masaharu Akao, Yasufumi Katanasaka, Genta Osakada, Hirofumi Kambara, Hiroki Shiomi, Takeshi Kimura, Akira Shimatsu, Koji Hasegawa, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan, University of Shizuoka, JapanBackground: Sigals acivae icrease hemoamic overloa o he hear iall reach uclei o cariomoces, chage paers o gee epressio a cause heir malaapive hperroph. Acelaio o hperroph-resposive rascripio acors a irisic hisoe acelraserase, p300, is a criical eve urig his process. Cariac p300 acivi is icrease i commo pes o hear ailure i which pahological cariomoce overgrowh occurs i respose o hemoamic overloa. A aural compou, curcumi, possesses hisoe acelraserase ihiior acivi wih speciici or p300. We have emosrae ha curcumi reame preves he eerioraio o ssolic ucio i wo iere ra moels o hear ailure, hperesio a mocarial iarcio. ecel, usig a ovel rug-eliver ssem, we have evelope highl asorpive curcumi. We hpohesize ha highl asorpive curcumi improves le vericular iasolic ucio i hperesive paies.Methods: Si eigh hperesive paies receive highl asorpive curcumi (60 mg/a, =30) or placeo (=38, a hisorical corol) ail or 24 wees. Ai-hperesive reame was coiue a uchage urig he su perio.Results: No averse eecs were oserve, a all paies complee he 24-wee ollow-up perio. Le vericular ucio was assesse wo-imesioal a Doppler echocariograph a aselie a a he e o ollow-up. The raio o earl iasolic rasmiral low veloci/earl iasolic veloci o miral aulus (E/e’), a parameer o iasolic ucio, improve i highl asorpive curcumi group (-11.2%, p<0.005 versus placeo group (+ 11.5%)). Meawhile, ssolic a iasolic loo pressures i o chage urig he perio.Conclusion: Treame o hperesive paies wih 60mg/a o highl asorpive curcumi is sae a well-olerale. Highl asorpive curcumi improves le vericular iasolic ucio regarless o loo pressure i hperesive paies.