Is There Any Association between CD14Polymorphism and Coronary Artery Disease

Background: Several pro-inflammatory single nucleotide polymorphisms have been associated with the development of atherosclerosis and coronary artery disease (CAD). CD14+ monocytes are one of these molecules due to their ability to produce variable cytokines. Association betweenCD14+ monocytes and carotid intimal-medial thickness has been previously identified. In this study, we tried to evaluate the relation between CD14 polymorphism and CAD. Methods: We evaluated 200 patients divided into two matched groups based on the result of their coronary angiography: 100 patients who had significant lesion(s) in their coronary arteries were allocated to the case group, and the other 100 without CAD were categorized as the control group. The polymorphism of CD14 was determined via allele-specific polymerase chain reaction (PCR). Results: The frequency of the genotypes (CC, TT, and CT) was 45%, 7%, and 48% in the case group and 24%, 38%, and 38% in the control group:there was a significant difference in the allele genotype frequency between the two groups (p value <0/001). Conclusion: CD14 polymorphism was associated with CAD. (Iranian Heart Journal 2012; 13(3):6-10 ).