Abstract 9032: Restoration of Normal Cardiomyocyte Basal and β-Adrenergic Receptor (AR) Subtype Modulation in Diabetic Cardiomyopathy by Chronic Selective Beta3-AR Antagonist in a Mouse Model of Type 2 Diabetes

Jing-Cao,Xiaoqiang Sun,Heng Cheng,Yixi Liu,Zhe Chen,David Zhao,Donald A. McClain,Dalane W. Kitzman,Che-Ping Cheng

Abstract 9032: Restoration of Normal Cardiomyocyte Basal and β-Adrenergic Receptor (AR) Subtype Modulation in Diabetic Cardiomyopathy by Chronic Selective Beta3-AR Antagonist in a Mouse Model of Type 2 Diabetes

2021

Jing-Cao
Xiaoqiang Sun
Heng Cheng
Yixi Liu
Zhe Chen
David Zhao
Donald A. McClain
Dalane W. Kitzman
Che-Ping Cheng

Background: We have shown that L-748,337 (L-7), a selective β3-adrenergic receptor (AR) antagonist reversed LV dysfunction and β-AR desensitization in diabetes (DM) caused diabetic cardiomyopathy (...

Keywords:

Desensitization (telecommunications)
Basal (phylogenetics)
Antagonist
Medicine
Endocrinology
Receptor
Beta blocker
Internal medicine
Type 2 diabetes
Diabetic cardiomyopathy
Diabetes mellitus

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