Experimental Infection of Sheep With Pseudorabies Viruses Isolated In Shanghai, China, Between 2010 and 2012
2017
For many years, pseudorabies has been efficiently
controlled in China by vaccination. However, a sudden
outbreak occurred on many pig farms during 2012-2013. In
this study, phylogenetic analysis was carried out with the
aim of understanding the genetic relatedness between
strains in both populations and comparing strains in China
with those circulating in other countries. To obtain more
pathogenetic relevant data regarding two pseudorabies
virus (PRV) isolates (SH2010 and SH2012) in sheep, we
evaluated samples of PRV isolated in Shanghai, China
between 2010 and 2012. Based on clinical signs, body
temperature variation, and the maximum amounts of viral
DNA in unvaccinated/infected sheep, the emerging PRV
variant strain, SH2012 was observed to be more highly
virulent than the traditional PRV SH2010 strain. The data of
the present study will aid in a better understanding of the
differences in pathogenicity between the traditional PRV
SH2010 strain and the emerging PRV variant strain SH2012.
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