588-P: Model-Derived Beta-Cell Function and One-Hour Glucose Best Predict Future Diabetes in a 14-year Longitudinal Large Cohort Study in South Korea

Considering ethnicity and disease heterogeneity, an early predictable index for future diabetes remains a challenge. As such, mathematical model-derived insulin sensitivity (mSI) and beta-cell function (mBCF) indices were estimated from oral glucose tolerance tests using the model of Ha and Sherman (AJP Endo 2020). Data from a 14 year longitudinal study in a Korean Population (baseline, Age 51.6±8.8 yrs, Male (50%), BMI 24.5±3.1 kg/m2, Figure A) were analyzed to identify the best predictor among fasting glucose (FG), one hour glucose (1hG), two hour glucose (2hG), HbA1c, and mBCF adjusted for mSI. Both adjusted mBCF and 1hG were the best predictors (adjusted by age, sex and BMI, both P Disclosure S. Ryang: None. Y. Kim: None. M. Yoo: None. H. Song: None. R. Rhee: None. J. Kim: None. H. Kang: None. A. Sherman: None. J. Kim: None. S. Kim: None. J. Ha: None. W. Yi: None. J. Kim: None. S. Bae: None. S. Jeong: None. M. Jang: None. M. Kim: None. Y. Kim: None. I. Kim: None.