Genotype of Potassium Inwardly Rectifying Channel, Subfamily J, Member 11 (KCNJ 11) Gene and Glycaemia Control in Diabetic Patients: A Narrative Review

ABSTRACT There are several factors that may affect the body response to the medicine and the drug response. One of the factors is the genetic variations. Some genes are predicted to have significant roles in oral antidiabetic response. This review is intended to define the role of Potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) genotypes to the glycemia control in Diabetes melitus type 2 (DMT2) patients. We conducted literature review using keywords “genotype description, kcnj11 gene, blood sugar level, diabetes melitus type 2” in Pubmed, Science Direct, BMC, PMC and Google Scholar database. Among the fourteen articles, we found that the most alleles studied was: rs5219 and rs5215. The homozygous wildtypes of rs5219 have no correlation with the risk of DMT2. However, the correlation between the allele of rs5219 and the medication response are still unclear. Furthermore, the correlation of alleles of rs5215 and the risk of DMT2 and medication response are still contradictive. The future studies are still needed to confirm the correlation between allele of rs5219, rs5215 and the risk of DMT2 and medication response.