Design, synthesis and biological evaluation of GY3-based derivatives for anti-type 2 diabetes activity

Abstract A series of indole carboxylic acid derivatives were designed and synthesized. Their anti-type 2 diabetes activity was evaluated in HepG2 cell and db / db mice. The results showed that compounds 8c , 17a , 17b , 15a and 15b could significantly increase glucose consumption in HepG2 cell. Furthermore, compound 8c was able to lower the blood glucose level and induce less weight gain in db / db mice.