Inhibitors of Bacterial Tyrosyl tRNA Synthetase: Synthesis of Carbocyclic Analogues of the Natural Product SB-219383

Richard Lewis Jarvest,John Michael Berge,Catherine S. V. Houge-Frydrych,Lucy Mensah,Peter J. O'Hanlon,Andrew J. Pope

Inhibitors of Bacterial Tyrosyl tRNA Synthetase: Synthesis of Carbocyclic Analogues of the Natural Product SB-219383

2001

Richard Lewis Jarvest
John Michael Berge
Catherine S. V. Houge-Frydrych
Lucy Mensah
Peter J. O'Hanlon
Andrew J. Pope

Carbocyclic analogues of the microbial metabolite SB-219383 have been synthesised and evaluated as inhibitors of bacterial tyrosyl tRNA synthetase. One compound showed highly potent and selective nanomolar inhibition.

Keywords:

Peptide synthesis
Natural product
Chemical synthesis
Enzyme
Metabolite
Enzyme inhibitor
Stereochemistry
Biochemistry
Tyrosine—tRNA ligase
Organic chemistry
Peptide
Chemistry
Dipeptide

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