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Catherine S. V. Houge-Frydrych

GlaxoSmithKline

22

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381

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Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity

2003 Bioorganic & Medicinal Chemistry Letters
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Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

2003 Bioorganic & Medicinal Chemistry Letters
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Inhibitors of Bacterial Tyrosyl tRNA Synthetase: Synthesis of Carbocyclic Analogues of the Natural Product SB-219383.

2002 ChemInform
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A Potent Seryl tRNA Synthetase Inhibitor SB-217452 Isolated from a Streptomyces Species.

2001 ChemInform
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Inhibitors of Bacterial Tyrosyl tRNA Synthetase: Synthesis of Carbocyclic Analogues of the Natural Product SB-219383

2001 Bioorganic & Medicinal Chemistry Letters
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Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors

2001 Protein Science
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Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase.

2001 ChemInform
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Lewis-acid catalysed arylation of the hydroxyamino sugar moiety of the natural product SB-219383

2001 Journal of The Chemical Society-perkin Transactions 1
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Sb-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp. Part 2. Structure Determination.

2000 ChemInform
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A potent seryl tRNA synthetase inhibitor SB-217452 isolated from a Streptomyces species.

2000 The Journal of Antibiotics
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Citations (77)